Weekly Administration Schedule
Weeks 1-4 (Loading)Protocol Updates (V7)
- MOTS-c: Reconstitute with 1ml water (not 3ml) to reduce injection volume and pain.
- GHK-Cu: Added to Friday/Sunday schedule. MUST be injected separately from all other peptides.
- Retatrutide: Monitor resting heart rate. If >15bpm increase, delay titration.
Est. Cycle Cost (12 Weeks)
£850.00
+ Buffer for supplies
Avg Daily Cost (Peak)
£11.45
During Loading Phase
Highest Cost Item
Retatrutide
~£16.00 per dose
Unit Economics Breakdown
| Peptide | Vial Cost | Doses/Vial | Cost Per Dose |
|---|---|---|---|
| Retatrutide | £80.00* | 5 | £16.00 |
| MOTS-c | £24.90 | 2 | £12.45 |
| TB-500 | £42.40 | 4 | £10.60 |
| Semax | £25.40 | 16 | £1.58 |
| BPC-157 | £30.40 | 20 | £1.52 |
| Selank | £18.90 | 16 | £1.18 |
BPC-157
The "Wolverine" Compound
3ml Mix Guide
Draw to line 15
(500mcg dose)
🔬 Mechanism of Action
Derived from a protein in human gastric juice, BPC-157 works primarily by upregulating VEGFR2 (Vascular Endothelial Growth Factor Receptor 2). This stimulates angiogenesis—the formation of new blood vessels—which is critical for healing avascular tissues like tendons and ligaments. It also modulates the FAK (Focal Adhesion Kinase) pathway to accelerate fibroblast migration.
🤝 Synergy & Stacking
The Wolverine Stack: Combine with TB-500. While BPC creates the vascular highways (angiogenesis), TB-500 upregulates Actin to help cells move along those highways to the injury site.
Note: Can be mixed in the same syringe.
⚠ Side Effects & Safety
- Anhedonia: Rare reports of dampened dopamine response. If noticed, discontinue.
- Nausea: Mild GI upset initially. Taking with food helps (if oral).
🔄 Off-Cycle Maintenance
To maintain gut/tissue health off-peptide:
- Zinc Carnosine (PepZin GI): Proven gut mucosal repair.
- Oral BPC (Arg-Salt): Stable in stomach acid, good for maintenance.
TB-500
Synthetic Thymosin Beta-4
3ml Mix Guide
Draw to line 75
(2.5mg dose)
🔬 Mechanism of Action
TB-500 functions by sequestering actin monomers. Actin is a protein essential for cell structure and movement. By maintaining a pool of available actin, TB-500 allows cells to rapidly polymerize filaments needed for cell migration (chemotaxis) to wound sites. It also creates a "scarless" healing environment by modulating pro-inflammatory cytokines.
🤝 Synergy & Stacking
Systemic Reach: Unlike BPC-157 which favors local injection, TB-500 is fully systemic. It pairs well with GHK-Cu for skin/collagen remodeling, but they must be injected separately. It is the "Mobilizer" to BPC's "Builder".
⚠ Side Effects & Safety
- Flu-Like Symptoms: Common during the "Loading Phase" (high dose). Temporary.
- Head Rush: Immediate vasodilation upon injection. Sit down when pinning.
🔄 Off-Cycle Maintenance
- Curcumin (Bioavailable): mimics the anti-inflammatory cytokine modulation.
- Hydrolyzed Collagen: Provides the raw glycine/proline needed for repair.
GHK-Cu
Copper Tripeptide-1
3ml Mix Guide (50mg Vial)
Draw to line 12
(2mg dose)
🔬 Mechanism of Action
GHK-Cu is a potent genomic modulator, capable of resetting the expression of nearly 4,000 genes to a younger state. It specifically upregulates Collagen I, Collagen III, and Elastin, while downregulating pro-inflammatory markers. It relies on the Copper (II) ion to activate enzymes like Lysyl Oxidase (for collagen cross-linking).
🚨 The Copper Incompatibility Rule
CRITICAL: Copper ions act as a Lewis Acid. If mixed in the same syringe with BPC-157, TB-500, or others, it will hydrolyze (break down) the peptide bonds of the other compounds, rendering them useless. ALWAYS INJECT SEPARATELY.
⚠ Side Effects & Safety
- Injection Pain: Copper is irritating. Dilute further if it burns.
- Zinc Depletion: High copper lowers zinc. Take a Zinc supplement (30mg) daily.
🔄 Off-Cycle Maintenance
- Topical GHK-Cu: Switch to creams/serums to maintain skin benefits without systemic loading.
- Vitamin C: Crucial for collagen synthesis (take away from GHK dose).
Semax
ACTH (4-10) Analogue
3ml Mix Guide
Draw to line 18
(300mcg dose)
🔬 Mechanism of Action
Semax rapidly elevates BDNF (Brain-Derived Neurotrophic Factor) and NGF (Nerve Growth Factor) in the hippocampus and frontal cortex. Unlike amphetamines, it modulates dopamine and serotonin receptors without depleting them, leading to a state of "Clean Focus" with neuroprotection against oxidative stress.
🤝 Synergy & Stacking
The Flow State Stack: Pair with Selank. Semax provides the "Drive/Focus" (Dopaminergic), while Selank provides "Calm" (GABAergic). Together, they eliminate the jitters associated with high focus, creating a stable productive state.
⚠ Side Effects & Safety
- Insomnia: Potent stimulation. Do not take after 2:00 PM.
- Hair Thinning: Rare anecdotal reports linked to chronic BDNF elevation.
🔄 Off-Cycle Maintenance
- Magnesium L-Threonate: Only form of Mg to cross blood-brain barrier for plasticity.
- Lion's Mane Mushroom: Natural NGF stimulator.
Selank
Tuftsin Analogue
3ml Mix Guide
Draw to line 18
(300mcg dose)
🔬 Mechanism of Action
Selank acts as an Enkephalinase Inhibitor, meaning it prevents the breakdown of your body's natural opioids (enkephalins). It also acts as an allosteric modulator of GABA receptors. This results in potent anxiolysis (anti-anxiety) without the sedation, memory loss, or addiction potential of benzodiazepines.
🤝 Synergy & Stacking
Social lubricant: Excellent to take 1 hour before social events or stressful meetings. Can be stacked with Semax during the day, or taken alone in the evening to wind down without causing drowsiness.
⚠ Side Effects & Safety
- No Sedation: Unlike Xanax, you won't "feel" it hit you. Do not overdose expecting a "high".
- Taste: Metallic taste common if used intranasally (drip).
🔄 Off-Cycle Maintenance
- Ashwagandha (KSM-66): Cortisol reduction.
- L-Theanine: GABA support without sedation.
MOTS-c
Mitochondrial-Derived Peptide
⚠ 1ml Mix Guide
Use 1ml Water ONLY (Not 3ml)
(5mg dose in 0.5ml)
Correction: Research indicates 3ml volume causes painful bolus. Use 1ml water to keep injection volume to 0.5ml.
🔬 Mechanism of Action
MOTS-c targets the Folate-AICAR-AMPK pathway. Upon metabolic stress, it moves to the nucleus to regulate genes involved in glucose metabolism. It stimulates GLUT4 translocation (forcing muscles to soak up glucose) and fatty acid oxidation, effectively mimicking the cellular signaling of intense exercise.
🤝 Synergy & Stacking
The Metabolic Pincer: Stack with Retatrutide. Retatrutide stops you from eating (input), while MOTS-c forces your mitochondria to burn energy (output). This prevents the "metabolic adaptation" (slowdown) common in dieting.
⚠ Side Effects & Safety
- ISR (Injection Site Reaction): Red, itchy hives are common. Take an antihistamine (Zyrtec) 1hr before.
- Fragile: Do not shake the vial. Swirl gently.
🔄 Off-Cycle Maintenance
- 5-Amino-1MQ: NNMT inhibitor that boosts NAD+ and metabolic rate.
- Berberine Phytosome: Activates AMPK similarly to MOTS-c.
Retatrutide
Triple Agonist (GLP-1/GIP/GCG)
3ml Mix Guide
Draw to line 60
(2mg dose)
🔬 Mechanism of Action
Known as "Triple G", it targets GLP-1 (Satiety), GIP (Insulin sensitivity/Lipid handling), and Glucagon (Energy Expenditure). The Glucagon component is the game changer—it increases hepatic thermogenesis, turning the liver into a fat-burning furnace, which explains the 24-30% weight loss seen in trials.
🤝 Synergy & Stacking
Muscle Preservation: Rapid weight loss is catabolic. You MUST stack this with high protein (1g/lb) and resistance training. Stacking with BPC-157 is highly recommended to protect the gut lining from the slowed gastric emptying.
⚠ Side Effects & Safety
- Heart Rate: Glucagon increases sympathetic drive. Monitor RHR. If it spikes >15bpm, lower dose.
- Hypoglycemia: Rare, but possible. Eat regular protein.
🔄 Off-Cycle Maintenance
- Yerba Mate: Mild GLP-1 stimulation.
- Fiber (Psyllium): Physical satiety to replace the drug's effect.